Assessing the role of LRRCl5 as a prognostic and therapeutic biomarker in glioblastoma.

ABSTRACT:

Objectives

Glioblastoma (GBM) is the most aggressive primary brain tumor, characterized by rapid progression and poor prognosis. Identifying novel biomarkers and therapeutic targets is crucial for improving GBM outcomes. This study aimed to explore the expression, prognostic value, therapeutic significance, and functional role of Leucine-Rich Repeat Containing 15 (LRRC15) in GBM.

Methods

We utilized data from multiple online databases to analyze LRRC15 expression and its prognostic significance. Mutational and methylation profiles were examined, followed by survival analyses. Experimental validation was conducted using reverse transcription quantitative polymerase chain reaction (RT-qPCR) and Western blotting in GBM cell lines. Functional assays, including colony formation,

SUBMITTER: Wan Z 

PROVIDER: S-EPMC12432708 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature