Knockdown of TIM1 enhances platinum chemosensitivity and inhibits progression through the MAPK signaling pathway in gastric cancer.

ABSTRACT:

Objectives

The incidence of gastric cancer (GC) is increasing worldwide, and it ranks among the leading causes of cancer-related mortality. Platinum-based chemotherapeutic agents are commonly employed in the treatment of various solid tumors; however, the development of drug resistance remains a crucial barrier to effective treatment. T cell immunoglobulin and mucin domain 1 (TIM1) has been implicated in the initiation and progression of various tumors. Nevertheless, the influence of TIM1 on the efficacy of platinum-based chemotherapeutics and its biologic implications in GC have not been thoroughly investigated.

Methods

This study utilized flow cytometry, cell counting kit-8 assays, and western blot to assess the role of TIM1 in modulating sensitivity to platinum drugs. Hig

SUBMITTER: Zhang C 

PROVIDER: S-EPMC12432751 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature