Identification of hub genes related to radiosensitivity and prognosis in rectal cancer.

ABSTRACT:

Background

Radiotherapy is one of the main treatment methods for rectal cancer (RC). However, radioresistance often leads to treatment failure and poor prognosis. This study aimed to explore the core molecules associated with radiosensitivity and prognosis of RC.

Methods

GSE133057 containing RC radiosensitivity information was downloaded from the Gene Expression Omnibus (GEO) database, and differentially expressed genes (DEGs) between the complete response (CR) group and the incomplete response (iCR) group were identified. Immune genes were obtained from the ImmPort database. Radiosensitivity-related immune genes (RRIGs) were obtained by intersecting DEGs and the immune genes. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were perform

SUBMITTER: Yang H 

PROVIDER: S-EPMC12432772 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature