The functional role of exosomal <i>miRNA-675-3p</i> derived from patients with hepatocellular carcinoma.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) is one of the most common solid tumors, resulting in poor survival and high mortality worldwide. MicroRNAs (miRNAs) contained in serum exosomes are being increasing used as targets for disease diagnosis and treatment. However, the role and the diagnostic potential of exosome-transported miRNAs in HCC remain largely underexplored. Therefore, this study aims to identify differentially expressed exosomal miRNAs in the serum of HCC patients and healthy individuals, clarify the biological function of the key miRNAs in HCC progression, and explore its potential as a diagnostic and therapeutic biomarker for HCC.

Methods

In this study, the serum-derived exosomes of patients with HCC and healthy individuals were characterized via transmission

SUBMITTER: Liang C 

PROVIDER: S-EPMC12432776 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature