Inhibition of SLC25A10 promotes cellular senescence and impedes hepatocellular carcinoma progression.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality with limited therapeutic options. Solute carrier family 25 member 10 (SLC25A10), a mitochondrial transporter linked to metabolic regulation and tumor progression, has unclear roles in HCC pathogenesis. This study aimed to elucidate the functional and mechanistic contributions of SLC25A10 to HCC development.

Methods

The International Cancer Genome Consortium (ICGC) database, GAO et al. dataset, quantitative real-time polymerase chain reaction (qRT-PCR), western blot (WB), and immunohistochemistry (IHC) staining were used to explore the expression levels of SLC25A10 in HCC tissues and cell lines. Functional assays [cell counting kit-8, colony formation, 5-ethynyl-2'-deoxyuridin

SUBMITTER: Ding YH 

PROVIDER: S-EPMC12432778 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature