MiR-378a-5p targets FGR to suppress proliferation, invasion and migration in lung adenocarcinoma cells.

ABSTRACT:

Background

Lung cancer (LC) remains the leading cause of cancer-related mortality worldwide. Emerging evidence demonstrates that microRNAs (miRNAs) serve as crucial post-transcriptional regulators in lung carcinogenesis. Previous studies have identified aberrant expression of miR-378a-5p in non-small cell lung cancer (NSCLC), although its precise regulatory mechanisms remain to be fully elucidated. This study aimed to investigate the mechanisms by which miR-378a-5p leads to the onset and progression of lung adenocarcinoma (LUAD).

Methods

LUAD's miR-378a-5p expression levels were examined utilizing publicly accessible databases. Quantitative real-time fluorescence polymerase chain reaction (qRT-PCR) was used to measure the expression of miR-378a-5p in LUAD tissues and nearby

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12432781 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature