Role of the transcription factor <i>SOX8</i> in hepatocellular carcinoma development and lymph node metastasis.

ABSTRACT:

Background

Lymph node metastasis (LNM) is one of the forms of hepatocellular carcinoma (HCC) dissemination, a phenomenon that is strongly correlated with an adverse prognosis. The transcription factor SOX8 has been implicated in tumor progression in other malignancies, but its prognostic significance and mechanistic role in HCC LNM remain unexplored. This study aims to explore the prognostic significance and mechanistic role of the transcription factor SOX8 in HCC LNM.

Methods

We retrospectively enrolled 387 HCC patients who underwent radical hepatectomy with lymph-node dissection between 2013 and 2021, among whom 57 were LNM-positive and the remaining 330 were negative. Recurrence-free survival (RFS) and overall survival (OS) were estimated using Kaplan-Meier

SUBMITTER: Teng X 

PROVIDER: S-EPMC12432789 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature