RHOJ enhances adhesion and proliferation capabilities and suppresses apoptosis of melanoma cells by activating the Rap1 signaling pathway.

ABSTRACT:

Background

Melanoma is an aggressive skin cancer derived from melanocytes, known for its high metastatic potential and poor prognosis. Understanding the molecular mechanisms underlying melanoma progression could provide novel therapeutic targets for improving treatment outcomes. Our study aims to investigate the role of the RHO family GTPase RHOJ in melanoma progression and its regulation of cell adhesion, proliferation, and apoptosis through the Rap1 signaling pathway.

Methods

The Gene Expression Omnibus (GEO) dataset GSE122907 and the Gene Expression Profiling Interactive Analysis (GEPIA) database were used to analyze differentially expressed genes related to melanoma. A375 cells were employed as the in vitro melanoma model. The STRING database was utilized to identify RHO

SUBMITTER: He X 

PROVIDER: S-EPMC12432792 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature