Altered DNA methylation of the ABO gene is associated with differential plasma levels of von willebrand factor and E-selectin.

ABSTRACT:

Background

The ABO blood group system is associated with differential susceptibility to thrombotic vascular diseases. ABO is also known to be a strong trans-protein quantitative trait locus for plasma proteins involved in cell adhesion and hemostasis.

Study design and method

To further investigate these associations, we integrated epigenomic, genomic, and proteomic data from the Milieu Intérieur cohort. We used the rs8176719 SNP to classify donors as either type O or non-O, and used linear models to compare levels of 229 plasma proteins in 400 donors, including age, sex, cytomegalovirus serostatus, and secretor status as covariates.

Results

We observed increased levels of soluble E-selectin and decreased levels of von Willebrand Factor (vWF) in O donors compared with

SUBMITTER: Lou T 

PROVIDER: S-EPMC12432810 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature