Tumor necrosis, an independent prognostic factor for predicting gastric gastrointestinal stromal tumors.

ABSTRACT:

Background

Tumor necrosis has been identified as an independent adverse prognostic factor in various human malignancies; however, its prognostic value in gastric gastrointestinal stromal tumors (gGISTs) remains uncertain. This study aimed to investigate the association between tumor necrosis and overall survival (OS) in patients with gGIST who underwent radical surgical resection.

Methods

In this retrospective cohort study, clinical and pathological data from 1,463 patients with gGIST were analyzed. The association between tumor necrosis and OS was assessed using univariate analysis with log-rank tests and multivariate analysis with Cox proportional hazards regression models.

Results

Tumor necrosis was observed in 238 patients (16.3%) and was significantly associated

SUBMITTER: Chang K 

PROVIDER: S-EPMC12432921 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature