Sarcopenia following concurrent chemoradiotherapy for locally advanced esophageal squamous cell carcinoma.

ABSTRACT:

Background

Multimodality treatment using chemotherapy, radiotherapy and surgery is standard practice for locally advanced esophageal squamous cell carcinoma (ESCC). Sarcopenia commonly occurs in patients with esophageal cancer. The effect of concurrent chemoradiotherapy (CCRT) on sarcopenia in patients with locally advanced ESCC remains unclear. We aimed to evaluate the effect of CCRT on sarcopenia in locally advanced ESCC.

Methods

This study included patients with locally advanced ESCC who received CCRT without surgery between 2011-2020. Sarcopenia was assessed using the skeletal muscle index (SMI) at the third lumbar vertebra (L3), which includes the psoas, paraspinal, and abdominal wall muscles, based on cross-sectional computed tomography (CT) scans before and after CCRT

SUBMITTER: Vongcharoenpol T 

PROVIDER: S-EPMC12432935 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature