Andrographolide potentiates anti-tumor immunity in colorectal cancer (CRC) by targeting voltage-dependent anion channel (VDAC) and activating the cGAS-STING axis.

ABSTRACT:

Background

Colorectal cancer (CRC) is a global health burden characterized by significant morbidity and mortality rates. While current therapeutic strategies, including surgical intervention and adjuvant chemotherapy, have shown moderate success, patients with advanced-stage CRC frequently encounter substantial therapeutic obstacles, primarily stemming from acquired drug resistance and tumor immune evasion. Emerging research suggests that phytochemicals are promising therapeutic candidates due to their pleiotropic regulatory capacities, particularly their capability to modulate immune checkpoint inhibitor (ICI) resistance pathways. These bioactive compounds could be used to develop novel therapeutic approaches based on the epigenetic reprogramming of tumor cells and the remodeling

SUBMITTER: Wu J 

PROVIDER: S-EPMC12432947 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature