Colorectal cancer prognosis: insights from the tumor immune microenvironment and gut microbiota.

ABSTRACT:

Background

Colorectal cancer (CRC) is the third most common cancer worldwide. Despite recent advancements in screening strategies and treatments, the prognosis of CRC patients remains poor. Emerging evidences suggest that tumor immune microenvironment (TIME) and gut microbiota play a pivotal role in CRC progression and treatment. However, the clinical utility of these findings remains limited due to the absence of robust biomarkers. We sought to establish a clinically actionable tool that could guide personalized treatment decisions and ultimately improve outcomes for CRC patients.

Methods

We analyzed differentially expressed genes (DEGs) from the Gene Expression Omnibus (GEO) and identified the prognostic genes for CRC by integrating the TIME- and gut microbiota-related gen

SUBMITTER: Chen Q 

PROVIDER: S-EPMC12432963 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature