Trauma Timing and Its Impact on Brain Activation During Flexible Emotion Regulation in PTSD: Insights From Functional MRI.

ABSTRACT: Patients with Post-Traumatic Stress Disorder (PTSD) exhibit deficits in flexible emotion regulation and display abnormal brain activation patterns. Previous research has not examined how the age at which trauma occurs influences associated behavioral and neural abnormalities. In this study, 76 adult participants (60.5% women) diagnosed with PTSD were categorized into three age-matched groups based on the age at trauma onset: childhood, adolescence, and adulthood. Forty-five healthy adults served as a control group. All participants engaged in the Shifted Attention Emotion Appraisal Task (SEAT) while undergoing functional magnetic resonance imaging (fMRI). Our findings reveal that both the childhood and adulthood trauma groups showed significantly greater activation in the left thalamus, le

SUBMITTER: Liu S 

PROVIDER: S-EPMC12432989 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature