Identification of the role of <i>ARG1</i> in the fibrotic process of benign airway stenosis using bioinformatics analysis.

ABSTRACT:

Background

Benign airway stenosis (BAS) is a disease characterized by the formation of fibrotic tissue leading to airway stenosis with unclear underlying molecular mechanisms. This study aimed to identify the key genes regulating fibrosis in BAS.

Methods

In this study, the fibrotic mechanism of BAS was explored through combined transcriptomic and proteomic analysis. We collected tracheal samples from day 7 of a mouse model of BAS, as well as from normal control mice. These samples underwent transcriptomic and proteomic sequencing, followed by integrative analysis to identify key genes associated with the condition. Subsequently, we assessed airway fibrosis in the BAS model mice after treatment with an inhibitor targeting the identified gene.

Results

The analysis revea

SUBMITTER: Chen Y 

PROVIDER: S-EPMC12433044 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature