The role of fecal short-chain fatty acids in neonatal necrotizing enterocolitis.

ABSTRACT:

Background

The metabolites of microbiota may contribute to the pathogenesis of neonatal necrotizing enterocolitis (NEC). The aim of this study was to explore the role of fecal short-chain fatty acids (SCFAs) in the development and progression of NEC.

Methods

This study was a retrospective case-control study. The included infants with NEC and non-NEC infants who were hospitalized during the same period were classified into the NEC and control groups, respectively. The concentrations of SCFAs were measured by chromatography-mass spectrometry analysis. The clinical data and concentrations of SCFAs were compared between the NEC and control groups. The association between clinical data, concentrations of SCFAs, and levels of C-reactive protein (CRP) and procalcitonin (PCT) was as

SUBMITTER: Li Y 

PROVIDER: S-EPMC12433050 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature