The role of the pleural fluid lactate dehydrogenase/adenosine deaminase ratio in differentiating between tuberculosis pleural effusion and parapneumonic effusion: a retrospective cohort study and meta-analysis.

ABSTRACT:

Background

In regions with a high prevalence of tuberculosis, it is crucial to accurately differentiate between tuberculosis pleural effusion (TPE) and parapneumonic effusion (PPE). The current study aimed to evaluate the potential role of the pleural fluid lactate dehydrogenase (LDH)/adenosine deaminase (ADA) ratio in differentiating between TPE and PPE.

Methods

In the first section, the pleural fluid LDH/ADA ratio was compared between 45 patients with TPE and 81 patients with PPE within our study population, and its diagnostic efficacy was assessed. In the second section, we conducted a meta-analysis incorporating six previous publications and the current study.

Results

In our study population, a cut-off value of 18.63 for the pleural fluid LDH/ADA ratio was establi

SUBMITTER: Shi XY 

PROVIDER: S-EPMC12433054 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature