Lipid metabolism-related genes regulate the immune microenvironment during ex vivo lung perfusion for lung transplants.

ABSTRACT:

Background

Ex vivo lung perfusion (EVLP) serves as a vital platform for donor lung assessment and repair in transplantation. Although lipid metabolism plays a crucial role in pulmonary homeostasis and undergoes alterations during EVLP, the precise regulatory mechanisms linking metabolic changes to immune modulation remain poorly understood. This study aimed to identify key lipid metabolism-related genes governing immune microenvironment remodeling during EVLP and to validate their diagnostic and therapeutic potential.

Methods

We analyzed transcriptomic profiles from human donor lungs before and after EVLP using datasets GSE127057 (discovery cohort) and GSE127055 (validation cohort). A comprehensive analytical framework was implemented, incorporating weighted gene co-expressi

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12433055 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature