Comparative analysis of clinicopathological characteristics and prognostic outcomes in fumarate hydratase-deficient renal cell carcinoma versus high-grade papillary renal cell carcinoma.

ABSTRACT:

Background

Papillary renal cell carcinoma (pRCC) is characterized by pronounced molecular and phenotypic heterogeneity. The traditional dichotomous classification was discontinued in the 2022 World Health Organization (WHO) Fifth Edition Classification, leading to the introduction of new renal cancer categories, including fumarate hydratase (FH)-deficient renal cell carcinoma (RCC). But there remains a significant risk of misdiagnosis between FH-deficient RCC and high-grade pRCC. Furthermore, existing studies rarely provide comprehensive comparative analyses of these types of renal cancer. This study aims to investigate the clinical and pathological characteristics, as well as the prognosis, of FH-deficient RCC and high-grade pRCC, thereby providing a basis for precise diagnosis.

SUBMITTER: Yu Y 

PROVIDER: S-EPMC12433056 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature