The impact of neuron-related cell adhesion molecule on cellular biological functions and its clinical significance in small-cell lung cancer.

ABSTRACT:

Background

Neuron-related cell adhesion molecule (NrCAM) has been implicated in tumor progression, but its role in small-cell lung cancer (SCLC) remains unclear. This study examined the clinical significance of NrCAM in SCLC and its impact on cellular processes.

Methods

Differentially expressed genes (DEGs) in SCLC were identified from The Cancer Genome Atlas (TCGA) datasets (GSE6044, GSE111044, and GSE44447) according to a |log fold change (FC)| >2 and a P value <0.05. Clinical and pathological data, along with tumor tissue samples, were obtained from 43 patients with SCLC treated at Nantong Tumor Hospital from 2017 to 2019. NrCAM expression was analyzed via immunohistochemistry. NrCAM knockdown or overexpression models were established in SCLC cell lines to evaluate

SUBMITTER: Li T 

PROVIDER: S-EPMC12433068 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature