Treatment needs in mild-to-moderate chronic obstructive pulmonary disease: evidence from longitudinal studies.

ABSTRACT:

Background

Mild-to-moderate chronic obstructive pulmonary disease (COPD) requires treatment to delay disease progression, but this need is often overlooked. We aim to identify common clinical indicators that can reflect the risk of disease progression, rapidly informing individualized and early-stage intervention strategies.

Methods

Patients in the placebo groups of two clinical trials (NCT01455129 and ChiCTR-IIR-17012604) were included as the discovery and validation cohorts. Patients with severe conditions [i.e., forced expiratory volume in one second (FEV₁) ≤60%, COPD assessment test (CAT) ≥10, or frequent acute exacerbations of COPD (AECOPD) history] at baseline or experienced annualized clinically important deterioration (CID, 60 mL in FEV₁, 2 poin

SUBMITTER: Wang Z 

PROVIDER: S-EPMC12433070 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature