Circular RNA circFTO promotes pressure overload-induced cardiac hypertrophy by encoding a novel protein FTO-36aa.

ABSTRACT:

Background

Pathological cardiac hypertrophy leading to ventricular remodeling poses a significant threat to human health. Circular RNAs (circRNAs) play a potential role in the dysregulation of cardiac hypertrophy, and recent evidence highlights their translational ability in various diseases. However, it is not clear whether circRNAs play a protein-coding role in myocardial hypertrophy and ventricular remodeling. This study aimed to investigate the role of circRNA derived from the fat mass and obesity-associated (FTO) gene (circFTO), a translatable circRNA, and the circFTO-encoded a 36 amino acid protein (FTO-36aa) in the pathogenesis of myocardial hypertrophy.

Methods

A transverse aortic constriction (TAC)-induced hypertrophy mouse model was established. The heart fu

SUBMITTER: Zhu RR 

PROVIDER: S-EPMC12433085 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature