Development and validation of a prognostic prediction model based on coagulation-related genes and clinical factors in acute leukemia.

ABSTRACT:

Background

Acute leukemia (AL) is one of the most prevalent pediatric malignancies with highly heterogeneous clinical outcomes. Coagulation-related genes (CRGs) play a crucial role in tumours, but their value in combination with clinical factors for prognostic prediction in AL is unclear. This study aims to develop a prognostic model based on the CRGs signature, with the goal of improving prognostic monitoring and identifying potential therapeutic targets for pediatric AL.

Methods

We collected transcriptomic and clinical data of pediatric AL patients from the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) and The Cancer Genome Atlas (TCGA) databases, including age, gender, and white blood cell count (WBC). Molecular subtypes related to CRGs wer

SUBMITTER: Lan T 

PROVIDER: S-EPMC12433087 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature