DDX18 promotes growth and metastasis of hepatocellular carcinoma via activating EMT and MAPK signaling.

ABSTRACT:

Background

DDX18, a member of the DEAD-box RNA helicase family, plays a pivotal role in ribosome biogenesis and RNA metabolism and is thus extensively implicated in tumorigenesis. Although its oncogenic functions have been well-documented across various malignancies, the precise molecular mechanisms underlying DDX18-driven progression in hepatocellular carcinoma (HCC) remain largely undefined. This study systematically elucidates the pathological contributions of DDX18 to HCC through a combination of comprehensive in vitro experiments and in vivo analyses.

Methods

We assessed the expression and effects of DDX18 on HCC tissues and cellular functions through bioinformatics analyses, wound healing assays, colony formation assays, transwell assays, and flow cytomet

SUBMITTER: Xu X 

PROVIDER: S-EPMC12433112 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature