Impact of obstructive sleep apnea severity and treatment on COVID-19 vaccine-induced immune responses.

ABSTRACT:

Background

Obstructive sleep apnea (OSA) is a common disorder linked to immune dysregulation and increased risk of severe coronavirus disease 2019 (COVID-19) outcomes. While vaccination is essential for preventing infection and severe disease, the impact of OSA on vaccine efficacy remains underexplored. This study examines the effects of OSA on immune responses following the third dose of the inactivated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine (CoronaVac or BBIBP-CorV).

Methods

A total of 97 severe OSA participants with apnea-hypopnea index (AHI) >30 events/hour, and 88 healthy donors (HDs) were enrolled. Among the OSA participants, 43 individuals without symptomatic treatment before and during follow-up were designated as the untreated OSA group

SUBMITTER: Chen L 

PROVIDER: S-EPMC12433113 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature