Effect of a novel implantable tibial nerve stimulation system on overactive bladder in pigs.

ABSTRACT:

Background

Overactive bladder (OAB) is a common and burdensome condition characterized by urgency, frequency, and urinary incontinence. While tibial nerve stimulation (TNS) has emerged as a minimally invasive neuromodulation therapy for OAB, current systems are limited by external devices, frequent hospital visits, and inconsistent stimulation. This study aims to investigate the safety and efficacy of a novel implantable TNS system for treating OAB in pigs.

Methods

Three male Bama miniature pigs (25-28 kg) received bilateral implantation of a novel battery-free, wireless implantable TNS system. The right-side device was activated as the treatment side, and the left-side device remained inactive as a control. Postoperative observations continued for 30 days, including assessm

SUBMITTER: Yu F 

PROVIDER: S-EPMC12433157 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature