Assessments of neurogenic bladder dysfunction induced by spinal cord injury, bladder outlet obstruction and diabetes: a comparative study of rat models.

ABSTRACT:

Background

Neurogenic bladder (NB) refers to urinary storage and voiding dysfunction resulting from neurological disorders. Animal models of NB are commonly used in preclinical studies, but the distinct characteristics of various modeling techniques are infrequently compared. This study aimed to evaluate and compare the functional and pathological outcomes of different NB rat models.

Methods

Three rat NB models were induced by spinal cord injury (SCI), bladder outlet obstruction (BOO), and diabetes. Blood urea nitrogen (BUN) and serum creatinine (Scr) levels, along with urine flow dynamics, were assessed at weeks 1, 2, 4, and 8. At the 10-week endpoint, animals were euthanized, and bladder weights were recorded for each specimen. Pathological analysis and western blotting we

SUBMITTER: Sun S 

PROVIDER: S-EPMC12433162 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature