Advanced Biomaterial for Dual-Drug Release: A Hydrogel-Microparticle Approach.

ABSTRACT: Advanced biomaterials with dual drug delivery represent a promising strategy to enhance therapeutic outcomes in wound treatment. This work aimed to combine antimicrobial and analgesic actions in a single platform, enabling the simultaneous release of both drugs from an advanced dual-drug delivery system based on a combined hydrogel and microparticle approach. The system was composed of alginate microparticles containing the antibiotic gentamicin incorporated into a gellan gum/collagen hydrogel matrix, in which the local anesthetic bupivacaine was directly loaded. The resulting composite was thoroughly characterized in terms of its morphological, physicochemical, mechanical, rheological, and thermal properties, as well as drug release profiles. The incorporation of microparticles significan

SUBMITTER: Garrido JGF 

PROVIDER: S-EPMC12433186 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature