Biochemical changes associated with non-alcoholic fatty liver disease in response to berberine treatment: a systematic review and meta-analysis of clinical and preclinical research.

ABSTRACT:

Background

Non-alcoholic fatty liver disease (NAFLD) represents a global health challenge. Berberine, an isoquinoline alkaloid traditionally used for metabolic disorders, has garnered attention for its potential therapeutic interventions.

Objective

To comprehensively review and perform a meta-analysis of berberine's effects on NAFLD across clinical and preclinical studies.

Methods

A comprehensive literature search was conducted across five databases from their inception to May 2024. We included randomized controlled trials and animal studies that evaluated berberine's impact on NAFLD using specified biochemical markers.

Results

Out of 487 screened studies, 22 (4 clinical and 18 preclinical) were included. Clinically, berberine significantly reduced fasting bloo

SUBMITTER: Zhu W 

PROVIDER: S-EPMC12433188 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature