Macluraparishin C Enhances Neuroprotection Against Oxidative Stress-Induced Neurodegeneration by Activating the Antioxidant/MAPK Signaling Pathway.

ABSTRACT: Oxidative stress plays a critical role in the development and progression of neurodegenerative diseases through the induction of neuronal injury and apoptosis. Macluraparishin C (MPC) is a novel parishin compound with identified potent neuroprotection, whose molecular mechanisms have not been clarified yet. The present research aims to explore the neuroprotective function of MPC in the context of the bilateral common carotid artery (BCCA) occlusion-induced transient global cerebral ischemia (tGCI) in gerbils, along with hydrogen peroxide (H₂O₂)-induced oxidative stress in SH-SY5Y cells. The neuroprotective capability of MPC was appraised by conducting several assays like cell viability, lactase dehydrogenase (LDH) assay, quantitative real-time PCR, Western blot, immun

SUBMITTER: Sabuj MSS 

PROVIDER: S-EPMC12433353 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature