Tertiary lymphoid structures gene signature predicts response to immunotherapy plus chemotherapy in advanced non-small cell lung cancer.

ABSTRACT:

Background

Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality, with chemoimmunotherapy (CIT) as the first-line standard for advanced NSCLC without driver mutations. However, predictive biomarkers for CIT response are limited. Tertiary lymphoid structures (TLS) play a critical role in antitumor immunity and may serve as potential biomarkers. This study aimed to screen and validate a TLS-derived gene signature to predict responses to first-line CIT in advanced NSCLC.

Methods

Data from three randomized trials (ORIENT-11, OAK, POPLAR) and The Cancer Genome Atlas-NSCLC were analyzed. TLS scores were computed via ssGSEA based on 17 TLS-related gene signatures. Patients were stratified into TLS-high and TLS-low groups. The predictive value was as

SUBMITTER: Du W 

PROVIDER: S-EPMC12433388 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature