Inherently bioactive iron-chelating Poly (N-acryloyl 2-glycine)/chitosan hydrogel scaffolds orchestrating dual hypoxic-immune microenvironment for functional meniscus regeneration.

ABSTRACT: Despite progress in tissue-engineered meniscus (TEM) as alternatives to meniscectomy, challenges remain in inflammatory regulation, oxidative resistance, and mechanical stability under pathological microenvironments. Innovatively, we combined personalized meniscus scaffold, hydrogel ion crosslinking network technology, and microenvironment regulation function to prepare a multifunctional poly (N-acryloyl 2-glycine)/chitosan (PACG/CS) composite hydrogel meniscus scaffold featuring heterogeneous bionic structure, high strength and toughness, hypoxic inducing activity, and anti-inflammatory and antioxidant effects. Crucially, the inherently bioactive hydrogel networks crucially leveraged their carboxyl groups to orchestrate iron ion chelation, establishing a hypoxia-mediated microenvironment

SUBMITTER: Xu B 

PROVIDER: S-EPMC12433485 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature