A hierarchical MgF₂/polyurethane/pitavastatin coating alleviates degradation and enhances endothelialization of bioresorbable magnesium alloy stents.

ABSTRACT: Rare-earth-free magnesium (Mg) alloy bioresorbable stent (BRS) exhibits significant potential in vascular intervention due to its exceptional biosafety. However, its susceptibility to corrosion complicates surface functionalization and renders existing coating strategies ineffective for degradation-remodeling kinetics, resulting in delayed re-endothelialization and excessive lumen loss. Herein, a hierarchical MgF₂/polyurethane (PU)/pitavastatin (PTV) coating system is constructed on Mg-Zn-Mn BRS using elastomeric PU as an intermediate layer. Studies confirm the PU layer effectively accommodates stent deformation, alleviates stress concentrations, and confines corrosion propagation triggered by deformation-induced MgF₂ microcracks. The in situ formed MgF_2</

SUBMITTER: Dou Z 

PROVIDER: S-EPMC12433515 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature