Establishing the super-enhancer landscape in chicken adipose tissue.

ABSTRACT: Enhancers are cis-regulatory elements that control spatiotemporal gene expression patterns. Super-enhancers (SEs), which function as clustered regulatory elements, play crucial roles in establishment and maintenance of cellular identity. Accumulating evidence highlights the importance of SEs in mammalian adipogenesis and fat deposition. However, adipocyte-specific SEs (ASSEs) in chicken adipose tissue have not been systematically characterized at the genome-wide level. In this study, we performed the Cleavage Under Targets and Tag mentation (CUT&Tag) profiling of H3K4me1, H3K27ac, and PPARγ binding in chicken adipose tissue. Integration of these three datasets led to the identification of 278 ASSEs, which were associated with 1,129 genes within ±100 kb window. Functional enrichment analysi

SUBMITTER: Mu F 

PROVIDER: S-EPMC12433516 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature