A computational neuroimaging study of reinforcement learning and goal-directed exploration in schizophrenia spectrum disorders.

ABSTRACT:

Background

Prior evidence indicates that negative symptom severity and cognitive deficits, in people with schizophrenia (PSZ), relate to measures of reward-seeking and loss-avoidance behavior (implicating the ventral striatum/VS), as well as uncertainty-driven exploration (reliant on rostrolateral prefrontal cortex/rlPFC). While neural correlates of reward-seeking and loss-avoidance have been examined in PSZ, neural correlates of uncertainty-driven exploration have not. Understanding neural correlates of uncertainty-driven exploration is an important next step that could reveal insights to how this mechanism of cognitive and negative symptoms manifest at a neural level.

Methods

We acquired fMRI data from 29 PSZ and 36 controls performing the Temporal Utility Integration deci

SUBMITTER: Culbreth AJ 

PROVIDER: S-EPMC12433706 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature