Gestational diabetes mellitus and its association with newborn thyroid screening: a population-based study.

ABSTRACT:

Objective

Gestational diabetes mellitus (GDM) affects maternal-fetal metabolism, but its impact on neonatal thyroid function remains unclear. This study aimed to evaluate the association between maternal GDM and total thyroxine (TT4) levels in newborn screening (NBS) and to identify contributing maternal and neonatal factors.

Methods

This observational cohort study linked national NBS thyroid data with hospital medical records. The cohort included 101,450 mother-infant dyads, comprising 4,643 GDM and 96,807 non-GDM singleton pregnancies with term liveborn offspring. Maternal GDM status was the primary exposure variable, and neonatal TT4 levels were assessed as the main outcome measure.

Results

The GDM prevalence was 4.6%. The median NBS TT4 levels (mg/dL) were 14.9 (1

SUBMITTER: Shoshan D 

PROVIDER: S-EPMC12433835 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature