The application of peripheral blood immune profiling in personalized treatment of locally advanced and advanced lung cancer: a nomogram approach.

ABSTRACT:

Purpose

Immunotherapy has revolutionized the treatment of lung cancer, yet many patients experience limited or transient benefits. Identifying those most likely to benefit remains a critical challenge. This study aims to establish a predictive model based on peripheral blood lymphocyte subsets to evaluate treatment responses in locally advanced and advanced lung cancer patients receiving chemotherapy with or without immunotherapy.

Methods

We prospectively enrolled 171 patients, peripheral blood lymphocyte subsets were analyzed pre-treatment, post-treatment, and at disease progression using flow cytometry, focusing on CD3^-CD16⁺CD56⁺ cells, CD3^-CD19⁺ cells, CD3⁺CD4⁺ T cells, CD4⁺/CD8^+<

SUBMITTER: Yin T 

PROVIDER: S-EPMC12433846 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature