Statin use and acute kidney injury among hospitalized chronic kidney disease patients: a retrospective cohort study.

ABSTRACT:

Background

Chronic kidney disease (CKD) constitutes a substantial burden in terms of cardiovascular disease and acute kidney injury (AKI). While statins are recommended for their cardiovascular benefits in CKD patients, their impact on AKI remains inconclusive.

Methods

A retrospective screening was conducted on all adult hospital admissions from January 1, 2018, to December 31, 2020, including patients with CKD. Statin exposure was defined as any prescription within 48 h of admission. Patients were monitored until death, discharge, or a maximum of 30 days. The primary outcome was in-hospital AKI, with in-hospital mortality as the secondary outcome.

Results

In a cohort of 5,376 patients, the median age was 72 years; 3,184 (59.2%) were male, and 2,129 (39.6%) were stati

SUBMITTER: Tang LE 

PROVIDER: S-EPMC12433938 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature