Efficacy of stem cell therapy for diabetic kidney disease: a systematic review and meta-analysis.

ABSTRACT:

Background/objectives

Animal studies have demonstrated the ability of stem cell therapy (SCT) to treat diabetic kidney disease (DKD). However, the efficacy of SCT in patients with DKD remain unclear. This systematic review and meta-analysis aimed to investigate the efficacy of SCT in patients with DKD.

Methods

A comprehensive and systematic literature search was conducted using PubMed, EMBASE, Cochrane Library, and Web of Science to identify articles on SCT for DKD published up to March 2024. RevMan V.5.4 software was used for statistical analysis.

Results

We identified four studies that included 90 participants, 53 (58%) of whom underwent SCT. SCT improved estimated glomerular filtration rate (eGFR) [mean difference (MD) = 0.41, 95% confidence interval (CI): 0.08-0.7

SUBMITTER: Du H 

PROVIDER: S-EPMC12433957 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature