Infectious bronchitis-virus-like QX strain transmission, pathogenesis, replication, and host miRNA biogenesis pathway hijacking mechanism.

ABSTRACT: The infectious bronchitis virus (IBV) is an acute, highly contagious, single-stranded RNA (ssRNA) gammacoronavirus mainly transmitted to chickens through the intranasal route. Positive-sense ssRNA viruses primarily act on mRNA and enhance the replication of viral copies. We identified the nasal entry site of the IBV-QX strain and provided insights into the minimal viral replication in systemic organs. Here is an overview of its entry mechanisms and tropism in systemic organ tissues. It enters the host cells via spike proteins, which bind to highly expressed receptors in respiratory, renal, and gastric epithelial cells. Viral RNA primarily replicates in the host cell environment, where it is directly translated into viral proteins. The precise replication of the IBV-QX strain in gastric epi

SUBMITTER: Khan A 

PROVIDER: S-EPMC12434004 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature