Plasma total and donor-derived cell-free DNA predict survival in kidney transplant recipients.

ABSTRACT:

Introduction

Studies evaluating cell-free DNA (cfDNA) in kidney allograft dysfunction have primarily focused on detection of rejection by donor-derived cfDNA (ddcfDNA). The utility of ddcfDNA as a marker of longer-term outcomes has not been examined.

Methods

This study investigated the prognostic value of plasma total cfDNA, fractional ddcfDNA and absolute ddcfDNA, quantified in 49 adult kidney transplant recipients (KTRs) at the time of indication allograft biopsy between 2014 and 2017. Primary outcomes were death, death-censored graft loss (DCGL), and all graft loss (AGL).

Results

During a median follow-up of 6.3 years, 7 patients died, 7 experienced DCGL, and 14 had AGL. Death was predicted by high total cfDNA [>4,034 copies/ml, hazard ratio (HR) 5.94, 95% CI 1.40-

SUBMITTER: Graver AS 

PROVIDER: S-EPMC12434054 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature