Changes in intestinal microbiota in patients with pancreatic cancer: a systematic review and meta-analysis.

ABSTRACT:

Background

Pancreatic cancer (PC) is a highly aggressive malignancy with an asymptomatic early stage, often resulting in rapid invasion of adjacent tissues and organs and a high mortality rate. Recent research has increasingly examined the gut microbiome as a potential factor in PC pathogenesis. Although changes in gut microbiota composition have been reported in patients with PC, a comprehensive evaluation of the relationship between gut microbiota and PC has not been systematically conducted.

Methods

A systematic search of PubMed, Web of Science, Embase, and Cochrane databases was conducted, and a meta-analysis was performed on 10 studies including a total of 324 patients with PC.

Results

The meta-analysis did not identify a statistically significant difference in <

SUBMITTER: Liang M 

PROVIDER: S-EPMC12434105 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature