Clinical value at baseline and follow-up of myeloperoxidase-antibodies in ANCA-associated vasculitis.

ABSTRACT:

Background

ANCA-associated vasculitides (AAV) are potentially organ- or life-threatening disorders that can cause irreversible damage if treatment is not started in time. The course of the disease may vary once remission has been achieved, with some patients experiencing relapses while others remain in sustained remission. The predictive value of PR3-ANCA for clinical deterioration is well established. However, limited data regarding MPO-ANCA, which has primarily been studied in microscopic polyangiitis (MPA) and eosinophilic granulomatosis with polyangiitis (EGPA), is less clear. This study aims to further clarify the role of MPO-ANCA in predicting relapse.

Methods

We conducted a retrospective review of the medical records of patients for whom positive MPO-ANCA serology was

SUBMITTER: Bossan G 

PROVIDER: S-EPMC12434123 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature