Energy-dense versus routine enteral nutrition in critically ill patients: a systematic review and meta-analysis.

ABSTRACT:

Background and aim

Critically ill patients often experience low target attainment rates with enteral nutrition (EN), leading to malnutrition and poor clinical outcomes. Energy-dense EN may improve caloric delivery and reduce the risk of malnutrition. However, its effects on other clinical outcomes remain unclear. This systematic review aimed to evaluate the impact of energy-dense EN in critically ill patients.

Methods

A systematic search was conducted in PubMed, Embase, Web of Science, Cochrane Library, Clinical Trials, China Knowledge Network Infrastructure (CNKI), Wanfang Data, and Weipu databases from inception to December 2024. Two researchers independently screened studies and extracted data. Randomized controlled trials (RCTs) comparing energy-dense EN with routine EN

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC12434126 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature