Evaluation of Treatment Effect of Sirolimus on Pediatric Pulmonary Vein Stenosis Using a Neonatal Rat Model.

ABSTRACT: A modified neonatal rat model of pulmonary vein stenosis (PVS) via bilateral pulmonary vein banding was introduced for the first time, providing a platform for understanding the pathophysiology of PVS and developing treatments. In addition, using this model, the mTOR inhibitor sirolimus was evaluated as a treatment for PVS and exhibited significant therapeutic effects, indicating the need for accelerated ethics approval in clinical settings where sirolimus is not yet in use.

SUBMITTER: Li D 

PROVIDER: S-EPMC12434204 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature