Baseline habitual dietary nitrate intake and Alzheimer's Disease related neuroimaging biomarkers in the Australian Imaging, Biomarkers and Lifestyle study of ageing.

ABSTRACT:

Background

Dietary nitrate, as a nitric oxide (NO) precursor, may support brain health and protect against dementia.

Objective

Our primary aim was to investigate whether dietary nitrate is associated with neuroimaging markers of brain health linked with Alzheimer's disease (AD).

Participants

Study participants were cognitively unimpaired individuals from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing (AIBL) who had β-amyloid positron emission tomography (PET) scans (n = 554) and magnetic resonance imaging (MRI) scans (n = 335) and had completed a Food Frequency Questionnaire at baseline.

Methods

Source-specific nitrate intakes were estimated using comprehensive nitrate food composition databases. Rates of cerebral β-amyloid (Aβ) deposition, me

SUBMITTER: Rajendra A 

PROVIDER: S-EPMC12434242 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature