Synergistic effects of copper and bile acids on cholesterol reduction in eggs of laying hens.

ABSTRACT: This study investigates the combined effects of copper (Cu) and bile acids (BA) on production performance, lipid metabolism, and antioxidant capacity in laying hens. During a 67-day trial, a total of 300 Jingfen 8 laying hens aged 160 days were randomly allocated into four treatment groups: Control (basal diet), Cu (25 mg/kg Cu), BA (500 mg/kg BA), and Mix (a combination of 25 mg/kg Cu and 500 mg/kg BA). The results indicated that the Mix group experienced a significant decrease in egg cholesterol levels, particularly in the yolk cholesterol content, along with an enhancement in the total antioxidant capacity. Additionally, the liver cholesterol metabolism was modulated by upregulation of CYP7A1 and ABCG5, alongside downregulation of SREBP-2 and HMGCR. While Cu and BA individually showed m

SUBMITTER: Chen H 

PROVIDER: S-EPMC12434248 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature