In Situ Evaluation of Macrophage Populations and Inflammasome Components in Cutaneous and Mucocutaneous Leishmaniasis.

ABSTRACT: American tegumentary leishmaniasis (ATL) affects the skin and mucous membranes, with a spectrum shaped by Th1/Th2 responses. This study investigated inflammasome activation in correlation with macrophage subpopulations, tissue parasitism, and histological changes in cutaneous and mucocutaneous leishmaniasis. We assessed inflammasome activation, tissue parasitism, and macrophage populations by immunohistochemistry, correlating with histopathological alterations using 29 biopsies from cutaneous and mucocutaneous leishmaniasis. Cutaneous leishmaniasis showed higher parasite density and infected macrophages than mucocutaneous leishmaniasis skin and mucosal lesions (p < 0.05). CD68⁺ and CD163⁺ macrophages were more abundant in cutaneous leishmaniasis (p < 0.0001 and p < 0.

SUBMITTER: de Heleno Chagas de Carvalho C 

PROVIDER: S-EPMC12434389 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature