A <i>Lactiplantibacillus plantarum</i>AL6-1 Strain Isolated From Air-Dried Meat Mitigates N-Dimethylnitrosamine-Induced Hepatic Injury in Mice.

ABSTRACT: Excessive intake of N-dimethylnitrosamine (NDMA) can lead to liver damage and carries a potential carcinogenic risk. This study screened a strain of Lactiplantibacillus plantarum (L. plantarum) AL6-1 from traditional fermented products in Inner Mongolia. The strain not only has the ability to degrade NDMA efficiently (the degradation rate is 73.62%), but also has better tolerance than other strains, and it has strong adhesion. These functional characteristics were further verified by genome-wide sequencing. Functional genes related to antioxidant activity, DNA repair, and metabolic regulation were also identified in the genome data, which provided a molecular basis for the protection of the strain against liver injury. Animal experiment results showed that intervention with <

SUBMITTER: Sun E 

PROVIDER: S-EPMC12434481 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature