Baseline Plasma GDF15 and Recovery of Physical Function Following Total Knee Replacement in The Study of Physical Resilience and Aging.

ABSTRACT: Growth-differentiation factor 15 (GDF15), a cytokine with the ability to regulate metabolic and inflammatory activity, is negatively associated with physical and cognitive function, and increases in circulation with age. Mechanistically, the expression of GDF15 is stimulated by mitochondrial stress across multiple tissues. We hypothesized elevations in basal circulating GDF15 were negatively associated with physical function following surgery in older adults. This was assessed in 112 Study of Physical Resilience and Aging (SPRING) participants (age 69.6 ± 6.9 years, 66% women) undergoing total knee replacement (RESTORE). The associations between pre-operative plasma GDF15 levels and longitudinal post-operative physical resilience measures including the Short Physical Performance Battery (S

SUBMITTER: Fountain WA 

PROVIDER: S-EPMC12434497 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature